A 65-year-old obese postmenopausal woman presented with complaint of bleeding per vagina for 2 weeks. On speculum examination, a cervical growth was observed on the posterior lip, measuring approximately 3 × 3 cm with bleeding ulcers (Fig. 1). A provisional diagnosis of carcinoma cervix was made. Pap smear examination and cervical punch biopsy was done for definitive diagnosis. Pap smear showed atypical squamous cells of undetermined significance. Histopathological examination revealed many amebic trophozoites lying amidst necroinflammatory debris along with a few desquamative squamous cells with reactive nuclear atypia. PAS-D (Fig. 2b) and Masson trichrome (Fig. 2c) special stains were used to highlight the amebic trophozoites. Diagnosis of cervical amoebiasis was made. The patient was started on tablet secnidazole 500 mg, 1 tablet per day for 2 weeks. She recovered following treatment (Fig. 3). Follow-up pap smear was done after 3 months which was normal.
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